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The clinical significance arises when B12 is elevated without a clear exogenous explanation

Healthcare professionals can find more details on Vitamin B12 treatment in guidelines

In adipose tissue, inhibition of NNMT suppresses de novo lipogenesis, normalizes fat content, and improves insulin sensitivity 2-3

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If the code is used under these circumstances, a brief, jargon-free note explaining the use of the code to the insurance carrier might be helpful in obtaining reimbursement