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The primary pathophysiology of Parkinsons disease is the death of dopaminergic neurons (dopamine-producing cells) and motoneurons in the midbrain (substantia nigra region)

Induced expression patterns of GPX genes under multiple phytohormone treatments in G

However, it is important to note that apoptotic cells can release DAMPs even in the absence of critical plasma membrane perturbations, in particular, via secretory lysosomes or exosomes [234, 235]

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doi: 10.1001/archpsyc.1994.03950030035004