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Modelling the blood-brain barrier: beyond the endothelial cells

doi: 10.2147/ndt.S420475 120 KoskuviMMalwadeSGracias LekanderJHrbeckEBrunoSHolmen LarssonJet al

M.KiserZ

High mobility group Box-1 and blood-brain barrier disruption

This functional polarity is finely modulated by membrane-bound proteins, receptors, channels, and transporters that govern essential processes such as ion homeostasis, neurotransmitter clearance, and neuroimmune signaling (Figure 4)