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En ese marco, los derivados de quinolinio como 5-Amino-1MQ (5-amino-1-metilquinolinio) emergieron como inhibidores de molcula pequea capaces de bloquear la metilacin de nicotinamida sin las limitaciones de biodisponibilidad de agentes de mayor tamao

William Castle demonstrated that gastric juice contained an "intrinsic factor" which when combined with meat ingestion resulted in absorption of the vitamin in this condition

Kraus, D., et al

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