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10.1016/j.jchemneu.2021.102037 189 ZhongZ.PatelA

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The characteristics of glutathione are the following: (a) discovered by Hopkins in 1921 [67], (b) synthesized intracellularly by glutamate-cysteine ligase and glutathione synthetase [68], (c) exists in reduced (GSH) and oxidized (GSSG) forms, maintaining cellular redox balance [69], (d) functions in melanogenesis inhibition through tyrosinase suppression and pheomelanin synthesis [70], and (e) oral bioavailability is enhanced through liposomal formulations, S -acetyl derivatives, or co-administration with precursors [71]

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The evidence regarding its impact on oxidative stress in migraine models remains limited, underscoring the need for careful consideration of dosages of topiramate and application conditions in the prophylactic treatment of migraines