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Anti-epileptic GAS which is the active ingredient in Gastrodiae Rhizoma is also reported to have antidepressant effects via protecting hippocampal neural stem cells from proinflammatory cytokine IL-1 [145]

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As a positive control for apoptosis, tamoxifen (50 M) was included ( 2 , 1.2 mM EGTA, 1.5% Nonidet P40, 0.3% CHAPS, 30% sucrose, 150 M caspase 3 substrate DEVD-AMC, 30 mM DTT, and 3.0 mM PMSF was directly added to HepG2 cells

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Despite these promising findings, the effectiveness of melatonin supplementation in ART can vary significantly depending on the specific stage of treatment and the individual context

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NSPs are synthesized as inactive zymogens and activated primarily by the ubiquitous enzyme dipeptidyl peptidase 1, also known as cathepsin C

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