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In rodent models, reported effects in tendon, ligament, muscle and gastrointestinal tissue have been attributed to modulation of the VEGFR2 / nitric oxide pathway, upregulation of growth-hormone receptor expression in fibroblasts, and effects on FAKpaxillin signalling that influence cell migration

As a result, BPC-157 and TB-500 are frequently discussed in research exploring muscle, tendon, and connective tissue biology

The Dept

But animal studies extending up to 6 months show no organ toxicity or adverse histological changes (Sikiric et al., Toxicology and Applied Pharmacology, 2019)

Here is where reconstitution connects to outcomes