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Actionable Takeaway Routinely screen patients for social isolation (e.g., recent bereavement, living alone, limited social contact) and implement mitigation strategiesstructured social engagement, therapy referrals, family/caregiver involvement, and follow-up touchpointsespecially in individuals showing increased irritability, anxiety, or aggression

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[8] Writing Committee Members et al

Evidence Quality Comparison# Side Effect and Safety Comparison# Dihexa Safety Considerations# The primary safety concern for Dihexa is specific to its mechanism

Adams PD, Afonine PV, Bunkoczi G, Chen VB, Davis IW, Echols N, et al