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It is commonly investigated in preclinical research models relating to metabolic signalling pathways, cellular energy regulation, and enzymatic activity associated with nicotinamide N-methyltransferase (NNMT) interaction studies

3 linked pagesOpen original pubmed-heffernan-aod9604-2001 AOD-9604 Clinical Trial Registry Entries: ClinicalTrials.gov ClinicalTrials.gov / U.S

doi: 10.1089/ars.2011.3999 46 KangJSunYDengYLiuQLiDLiuYet al

A compound that produces identical protective effects whether administered systemically or topically to the target tissue suggests both a circulating effector mechanism and a local tissue-level mechanism, consistent with the dual NO-VEGF angiogenic pathway described above

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