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This review provides a concise overview of new directions in treatment development for TRD, including treatments targeting the glutamate system, the opioid system, inflammatory signalling systems and others

Dietary modifications, such as adopting a fibre-rich diet, can help regulate bile acids and bilirubin levels, reducing the risk of supersaturation and precipitation

Additionally, they found a significant reduction in GPX4 and xCT proteins in mice treated with Con A

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