Indeed, GSH, Trx, Grx, Prx (together with the enzymes catalyzing their reduction), and the enzymatic antioxidant defense, as a whole, concur to modulate either ROS concentration, or the availability of cellular thiols, thus regulating the function of a large number of proteins implicated in the induction and/or execution of redox-sensitive pathways
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Reduced glutathione (GSH) is a tripeptide (g-glutamylcysteinylglycine) and plays a key role in preventing oxidative damage in living organisms
Thats because liver cells rely on antioxidant glutathione during normal detoxification activities
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