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Concretely, EC-derived lactate induces histone Kla, particularly H3K18la, which promotes the differentiation of bone mesenchymal stem cells (BMSCs) into osteoblasts by activating osteogenic genes such as COL1A2, COMP, ENPP1, and TCF7L2

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PMID: 11713213

Okabe and Amagase, 2005) would define agents action

Vegetarians & Vegans Older adults People with pernicious anemia or GI absorption disorders (like Crohn's or celiac disease) Individuals after certain surgeries (such as gastric bypass) Pregnant women People on chronic metformin or proton pump inhibitors (PPIs) How much does a B12 shot typically cost