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The scratch areas were measured using Image J software
To this end, BALB/c mice, which are genetically deficient in endogenous melatonin production (28), were intranasally challenged with 25 g Alternaria alternata (AA) or PBS daily for four days, with or without concurrent intraperitoneal melatonin treatment using established protocols described previously (18, 2931) ( Figure 1A )
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In CTR-1011, injection-site issues happened in 50.7% of tesamorelin users versus 21.4% on placebo