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Journal of Molecular Medicine , 2017

The review confirmed that NNMT-mediated NAD+ depletion impairs mitochondrial function, SIRT activity (particularly SIRT1 and SIRT3), redox balance, and energy metabolism, creating conditions relevant to cardiovascular disease research models

The transcription factor Egr-1: a potential drug in wound healing and tissue repair

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The medication was applied either once at 1 min after defect creation as an abdominal bath (1 mL/rat), or intraperitoneally once daily, with the first application at 30 min after surgery and the last application 24 h before the assessment