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Early investigation revealed that cigarette smoke initiated the MAPK signaling pathways, which in turn regulated the activation of transcription factors (TFs) and affected DNA-binding capacity of more than 20 TFs, including nuclear factor-kappa B (NFB) [140]

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Erb-Downward JR, Thompson DL, Han MK, Freeman CM, McCloskey L, Schmidt LA, Young VB, Toews GB, Curtis JL, Sundaram B, et al

Once the tobacco has been purchased, it is shipped to a local processing factory where the leaves are further processed and dried for uniformity