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Its primary function is G-actin sequestration TB4 binds monomeric actin with nanomolar affinity, regulates the polymerizable actin pool, and indirectly governs cytoskeletal dynamics during cell migration, wound healing and inflammatory response

Pharmaceut Res

While there is limited research specifically addressing the safety of this combination, we can look at the individual properties of both substances to draw some conclusions

Each requires a delivery technology like microinfusion to reach the dermis where fibroblasts live