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1,2,33 Excessive ROS levels may cause serious oxidative damage, which can be reduced by an antioxidant system formed by SODs, catalases, MAPKS, SIRTs, GSH, vitamin C and E

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A study that simultaneously controlled for MDD, tobacco use disorder, MetS, and generalized anxiety disorder revealed that partially shared ROS/RNS, along with O&NS pathways, underlie the comorbidity of mood disorders, MetS, and generalized anxiety disorder [154]