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Under physiological conditions, wildtype syn is efficiently degraded via CMA

pH Effect of GSH on Antibacterial Activity GSH is composed of three amino acids with two free -carboxyl groups from Table 4

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GSH production is supported by NRF2 through controlling several enzymes responsible for GSH synthesis, such as the glutamate-cysteine ligase (GCL) complex composed of two subunits, the modifier (GCLM) subunit and the catalytic (GCLC) subunit, which catalyze the rate-limiting step of GSH synthesis that converts cysteine and glutamate into GSH [22]

This review has delineated the physiological and pathological roles of O-GlcNAcylation, elucidated the molecular mechanisms underpinning these functions, and underscored its protective potential in CNS diseases