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The uptake values for the nanocarriers at the 4-h time-point were 3.2 ng/g protein in the non-targeted 3-PLG-dopa and 0.4 ng/g protein in the 3-PLG-ibu groups (Fig

Notably, this reduction in systemic LPS was accompanied by a down-regulation of pro-inflammatory mediators (e.g., TLR4, NF-B, and IL-6) in the uterus, suggesting that butyrate can alleviate high-grain induced inflammation across the gut-uterus axis by fortifying the epithelial barrier 166

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