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Two doses of 3 g each lead to the same total uptake as a single dose of 150 g: Multiple doses of 3 g : 2 x 1.5 g = 3 g Single dose of 150 g : 1.5 + 150/100 g = 3 g If you would rather cover your vitamin B12 requirement with small doses, it is best to split your intake into three

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[1] In moderate deficiencies, feeling tired, feeling faint, mouth ulcers, rapid breathing, upset stomach, pallor, hair loss, decreased ability to think and joint pain and the beginning of neurological symptoms, including abnormal sensations such as, numbness and tingling, and tinnitus may occur

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Al-dulaimi S, Thomas R, Matta S, Roberts T