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However, with age it can become harder to absorb

Next-generation mucosally targeted vaccines may be able to draw T and B cells from the blood and lymphatics into the mucosa, prime de novo responses locally, or even boost immunity generated by previous infections of the airways

however, the studies included in the pooled analysis were too heterogeneous to inform an association (140)

The oral activity seen in rodents cannot be directly mapped to human oral dosing without pharmacokinetic bridging studies, which do not exist for BPC-157