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Curcumin possesses antioxidant capabilities by stimulating phase II detoxifying enzymes such as glutathione S-transferase (GST), UDP-glucuronosyltransferase, and heme oxygenase-1 (HO-1)

Additionally, ex vivo exposure of amniotic fibroblasts to cortisol, endotoxin, or both led to increased 11-HSD1 expression (300)

Activation of caspase-8 facilitates the execution of apoptosis, simultaneously inhibiting necroptosis by preventing RIPK1 recruitment, a key regulator of necroptosis

These particles are now recognized as a novel environmental stressor of the nervous system