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There are accounts of potential toxicity or side effects that are not yet fully mapped, and some researchers have voiced public concerns with both safety and efficacy

Rajan, R., Hayashi, F., Nagashima, T

If the window is wasted, if the person relies entirely on the appetite suppression without changing their food environment, cooking skills, or activity level, regain after discontinuation is nearly inevitable

In fact, using the lowest effective dose is the approach most researchers recommend

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