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Description

Large-scale randomized controlled trials meeting Western regulatory standards have not been conducted

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Its overactivation disrupts nicotinamide metabolism, reduces NAD+ levels, promotes hepatic lipid accumulation and lipotoxicity, and represents an important therapeutic target for hepatic metabolic disorders

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NicheHotSpotter, a general framework for cell-niche inference that integrates signaling interactomes with gene regulatory networks, was applied to skeletal muscle to prioritize insulin-like growth factor-1 (IGF-1)/Akt-centered nodes linked to age-associated MuSC decline

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Schnurr, K., Belkner, J., Ursini, F., Schewe, T

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