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Integrins affect the microtubule cytoskeleton by promoting microtubule nucleation, growth, and stabilization, whereas microtubules impact integrin function by targeting integrin adhesions to promote their turnover

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Additionally, inhibition of the mammalian target of rapamycin (mTOR) with everolimus reduced the levels of tau and amyloid precursor protein/amyloid (APP/A) and improved cognitive function