8e), despite the accumulation of intracellular 5FU and continued TS inhibition
Outcome indicators: studies reporting any association related to the pathway nutrients [e.g., dietary fiber, omega-3 polyunsaturated fatty acids (PUFAs)] intestinal inflammation depression, including but not limited to intestinal inflammation markers [e.g., interleukin-6 (IL-6), Tumor necrosis factor- (TNF-)], depression assessment scores [e.g., Beck Depression Inventory-II (BDI-II), Patient Health Questionnaire-9 (PHQ-9)], and changes in gut microbiota composition
Lindenau et al., In 2006, the World Health Organization recognized SCD as a global problem with significant economic implications with the incidence expected to rise above 400,000 births per year in 2050 (Piel et al., 2013a
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