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Although the insulas role in interoceptive monitoring has been well characterized [80] and higher nAChR availability in the thalamus, PFC, and cerebellum has been positively correlated with increased pain sensitivity among abstinent smokers [96], relatively little neuroimaging work has focused on the neurobiological processes that may contribute to smoking- or withdrawal-related pain dysregulation

In July 2013, the FDA published its own report that also concluded that the removal of menthol cigarettes from the market would improve public health

Prevalence of smoking in psychiatric patients

Habitual smokers who started smoking in adolescence appear to be more at risk of developing insomnia than those who started later in life 8 or those who smoke infrequently