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Further studies have found that P53 can inhibit system Xc- uptake of cystine by downregulating the expression of SLC7A11, thereby affecting the activity of GPX4 and resulting in the reduction of antioxidant capacity, ROS accumulation, and ferroptosis 11

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Gibney GT, Aziz SA, Camp RL, Conrad P, Schwartz BE, Chen CR, et al

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