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Following the assay, the supernatant was aliquoted and stored at 80 C for further analysis

Although direct quantification of peroxisomal -oxidation defects in PACs is still lacking, the available metabolic framework strongly suggests that failure of this buffering pathway may be one of the underrecognized amplifiers of lipotoxic injury in HTG-AP rather than a merely secondary epiphenomenon

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Additionally, many studies with tolerability data involve combination creams, making it difficult to assess glutathiones specific tolerability