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Requirements of vitamin B12 in excess of normal (due to pregnancy, thyrotoxicosis, hemolytic anemia, hemorrhage, malignancy, hepatic and renal disease) can usually be met with intranasal or oral supplementation

Patients typically lose 5070% of excess weight within 1218 months, though results vary considerably

bacteriostatic water is a US-centric product not routinely stocked or licensed as a standard diluent in the UK

Benzyl alcohol in bacteriostatic water is contraindicated in neonates and premature infants, and any diluent used must be the one specified by the product sponsor