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Rosuvastatin decreases caveolin-1 and improves nitric oxide-dependent heart rate and blood pressure variability in apolipoprotein E-/- mice in vivo

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Toll-like receptor misrecognition is considered to be an important step in alpha-synucleinopathy progression, and increased intestinal permeability, immune activation, and enteric neuroglial activation are keys in the pathophysiology of Parkinsons disease (158)

Nasal delivery skips this entire process, potentially leading to higher bioavailability for certain molecules

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