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Immediate medical attention is warranted if missed periods are accompanied by concerning symptoms such as severe abdominal pain, heavy bleeding, abnormal vaginal discharge, signs of pregnancy, symptoms of thyroid dysfunction (significant fatigue, cold intolerance, hair loss), or signs of hyperprolactinaemia (galactorrhoea, visual disturbances, headaches)

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A reaction that might be mild and manageable at conservative doses becomes more significant at intensive levels