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Discussion In summary, this study reports on the rational design, synthesis, and in-depth biological evaluation of tumor-targeting ruthenium containing nanoreactors for glutathione oxidation catalysis in osteosarcoma cells with a 1% O 2 atmosphere

In addition, we investigated the metabolic fate of U- 13 C glutamine, which produces -GC and GSH containing five 13 C atoms via GSH de novo synthesis (Fig

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