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constructed an NIR-responsive nanoplatform (rPOMs@MSNs@copolymer), using mesoporous silica nanoparticles (MSNs) and rPOMs, which enhanced bioavailability and BBB penetrability [113]

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In patients taking opioids for an extended period of time at high doses, ensure that a multimodal approach to pain management, including mental health support (if needed), is in place prior to initiating an opioid analgesic taper [see DOSAGE AND ADMINISTRATION, and WARNINGS]