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In vivo animal experiments showed that daily administration of NNMTi for 28 days to dietinduced obese (DIO) mice significantly upregulated the expression of lipolysisrelated genes (such as ATGL and HSL) and downregulated lipogenesisrelated genes (such as FAS and ACC), indicating that NNMTi effectively promotes fat breakdown and inhibits fat synthesis
Additional studies could be directed toward optimizing delivery techniques, dosing schedules, product stability, and intranasal formulations
Likewise, it has been previously reported that HSV infection-induced ROS are responsible for the formation of lipid peroxidation byproducts and neurotoxicity, characteristic of encephalitis [40], [41]
Dynamics within the CD95 deathinducing signaling complex decide life and death of cells
Signal Transduct Target Ther 10:74
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