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Another randomized controlled trial with 52 MS patients showed that ALA significantly decreased the serum levels of proinflammatory mediators, including ICAM-1, IL-4, TGF-, and IFN-, compared to controls [71]

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Experimental data point oxidative stress as one of the factors that contributes to aquaporin-1 up-regulation since administration of the antioxidant melatonin not only reduced protein levels but also mechanical allodynia and appearance of aquaporin-1-positive fibers below laminae I and II (Nesic et al., 2008)