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When nicotine levels drop, the brain experiences withdrawal, leading to tobacco side effects and symptoms such as: Irritability or restlessness Difficulty concentrating Anxiety or nervousness These withdrawal symptoms and the craving for dopamine lead to a cycle of addiction, making it difficult to quit
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These findings should be interpreted with caution because this was a very short-term investigation (only 6 weeks), and the authors of that research had connections with nicotine pouch manufacturers [53]
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