Glutamateglutamine cycling Biochemical pathway that describes the uptake and conversion of glutamate to glutamine by astrocytes and the subsequent transfer of glutamine back to neurons for conversion to glutamate
doi: 10.1016/j.sajb.2021.05.022 24
A main problem with adenosine receptor-based therapies, in particular those directed towards the ubiquitous neuroprotective receptor, the adenosine A 1 receptor, is the side effects
Based on the working hypothesis of P-gp-dependent collateral sensitivity [14,15,16,17], we examined the ability of tamoxifen as a collateral sensitivity drug for two reasons: a) tamoxifen has been previously shown to activate P-gp ATPase at clinically achievable concentration (46 M) [20, 21], and b) tamoxifen is widely used in the treatment of estrogen receptor-positive breast cancer [22]
And always remember: if any of these symptoms become particularly uncomfortable, you can always come to talk to me