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Melatonin was shown to decrease surgery-associated anxiety and pain (6) , frequency of migraine attacks (7) and perioperative anxiety (30) (56) , but there is insufficient evidence for its use to improve delirium in hospitalized patients (57) , to improve depression or depressive symptoms (47) , or for seasonal affective disorder (SAD) (48)

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The intravenous safety study published in 2025 involved only 2 participants