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Mechanistically, the NRF2/FSP1 axis is the key endogenous antioxidant pathway mediating the inhibition of VSMC ferroptosis and AS, although the precise regulatory mechanisms remain fully elucidated [95]

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These results underscore the fact that the efficacy of glutathione as a skin-lightening agent depends on consistent use and the dosage administered

It not only molecularly links oxidative stress and iron dyshomeostasis with classical protein pathologies, forming an integrated pathogenic framework of iron-A/tau-neuronal death, but also reveals an actionable cell death execution pathway

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