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Pathogenesis Arises from fat-storing perisinusoidal cells, so-called Ito cells

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Further, probiotics modulate the immune response by enhancing the intestinal barrier function through regulation of tight junction proteins, thereby promoting anti-inflammatory cytokine production, and potentially activating antigen-presenting cells (APCs) that prime tumor-specific T cells (248)

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Research suggests timing matters: applying cold therapy 30-60 minutes before or after BPC-157 injection may optimize outcomes by leveraging their complementary mechanisms