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Maintenance dosing after achieving weight loss often allows reduction to 1.8-2.0mg weekly while sustaining results, providing cost savings and better tolerability for long-term use

Patients experience reflux caused by frequent LES relaxations rather than excessive acid production

Potential tumor promotion : Given its angiogenic properties, there is theoretical concern it could contribute to tumor growth or neovascularization in certain contexts

Intersection concept: migration and remodeling biology (actin-driven movement + repair program signaling) provides a mechanistic bridge for evaluating combinations

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