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[DOI] [PMC free article] [PubMed] [Google Scholar] 15.The Role of Amyloid- Oligomers in Toxicity, Propagation, and Immunotherapy

If you experience these persistently, it's important to inform your doctor

However, investigation of the effect of UA on such models is limited by the profound differences between humans and e.g., rodents in UA metabolism, primarily due to the loss in humans of a functional uricase

Future research should focus on large, multicentre trials, optimization of pharmacokinetics and comprehensive safety profiling to substantiate the efficiency in various patient populations and molecular subgroups

In the animal experiments, animals were randomly grouped and coded by an independent individual, and both the experimenters and data analysts were blinded to the group allocations