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Retinoic acid (RA) or tretinoin, in concentrations of 1%, 3%, and 5% in ethanol/propylene glycol, was first reported in 2001 as an agent for serial superficial peelings and indicated for melasma and photoaging [103, 104]

Allow several weeks to notice trends

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Biochim Biophys Acta 1863:29772992 Senger DR, Li D, Jaminet SC, Cao S (2016) Activation of the Nrf2 cell defense pathway by ancient foods: disease prevention by important molecules and microbes lost from the modern western diet