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In particular, nano-formulation strategiesincluding polymeric nanoparticles, lipid-based nanocarriers, nanoemulsions, and micellar systemshave shown promise in improving solubility, stability, and pharmacokinetic behavior

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Most of the GCL holoenzyme can be reversibly dissociated by treatment with dithiothreitol [42], while oxidative stress may enhance holoenzyme formation as it increases GCL activity in the absence of any change in the expression of GCL subunits [45]