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Human (epithalamin): A 6-year follow-up of elderly patients treated with epithalamin showed 1.6-1.8-fold reduction in mortality, and a 15-year observation with combined pineal and thymus peptides showed 2.5-fold reduction (Khavinson & Morozov, 2003)

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A 2025 systematic review in the International Journal of Dermatology documented liver function abnormalities in approximately half of IV-treated participants at high doses, which is why DermaVue restricts treatment to evidence-based clinical doses of 400 to 1200 mg with mandatory hepatic monitoring