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doi:10.1074/jbc.M512655200

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Cancer Metastasis Rev 44(1):36 Nabakhteh S et al (2025) Nutritional interventions in amyotrophic lateral sclerosis: from ketogenic diet and neuroprotective nutrients to the microbiota-gut-brain axis regulation

GI disease, food allergies, age, stress, and taking drugs and or medications can cause a decrease in activity of any of these, and therefore will lead to B12 deficiency

It also plays a major role in detoxifying chemicals in the liver via a series of enzymes which transform hormones and chemicals into water-soluble elements that can be excreted through the intestines, kidneys and skin