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The even burn ensures that the joint does not burn unevenly or too quickly a common problem with incorrect tobacco choice

Between subjects, participants received each cigarette type in either light pale blue (Natural American Spirit Sky) or dark black (Natural American Spirit Black) packaging to represent extremities along a continuum of implicit harm (i.e., light = low harm, dark = high harm)

To validate the RNA-Seq findings, we assessed inflammatory indicators by measuring white blood cell (WBC) count and IL-6, CXCL15, and TNF- levels in BALF using ELISA

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