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Topicals are low barrier entry, microneedling can raise penetration, and injections or mesotherapy require clinic sterility and close follow-up

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Their small, linear structures facilitate easier synthesis, high water solubility, and effective diffusion across biological barriers

1) Cell type- and nephron segment-specific susceptibility: The kidney is a highly heterogeneous organ, with distinct nephron segments [PT, distal tubule (DT), collecting duct (CD)] and cell types (podocytes, mesangial cells, interstitial fibroblasts, and endothelial cells) exhibiting divergent ferroptosis susceptibility