In addition, the development of immunopeptidome analysis should provide successful targets and open the way to a new generation of senolytic treatments
The hallmark of NAFLD is hepatic steatosis, but the disease also encompasses non-alcoholic steatohepatitis (NASH) characterized by hepatic inflammation, hepatocyte damage, and fibrosis, highlighting the potentially progressive nature of the disease
498 The key pathological features of AD are the accumulation of A-enriched neuritic plaques and neurofibrillary tangles (NFTs) (consisting of tau protein)
As the primary organ responsible for steroid metabolism, the liver is particularly susceptible to the toxic effects of 17--alkylated oral anabolicandrogenic steroids, such as stanozolol and methyltestosterone ( Mechanistic studies suggest that anabolicandrogenic steroids impair mitochondrial -oxidation and deplete intracellular glutathione stores, resulting in lipid peroxidation and activation of apoptotic signalling pathways
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